Higher-order organization of biomolecular condensates
Year: 2021
Type: review
Abstract: A guiding principle of biology is that biochemical reactions must be organized in space and time. One way this spatio-temporal organization is achieved is through liquid-liquid phase separation (LLPS), which generates biomolecular condensates. These condensates are dynamic and reactive, and often contain a complex mixture of proteins and nucleic acids. In this review, we discuss how underlying physical and chemical processes generate internal condensate architectures. We then outline the diverse condensate architectures that are observed in biological systems. Finally, we discuss how specific condensate organization is critical for specific biological functions.
Source: Open Biology
DOI: 10.1098/rsob.210137
Institution: University of Pennsylvania
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,839
Awards: Structural biology & molecular biophysics training program, Programming human protein disaggregases against FTD, Defining mechanisms of AAA+ disaggregases, Isolating small-molecule enhancers of the human alpha-synuclein disaggregase machinery, Engineering KapB2 to Disaggregate Disease-Linked Proteins, Vanderbilt Interdisciplinary Training Program in Alzheimer's Disease
OpenAlex ID: W3171235999