Work

Vancomycin Is Protective in a Neonatal Mouse Model ofStaphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain Injury

Year: 2019

Type: article

Abstract: Infection is correlated with increased risk of neurodevelopmental sequelae in preterm infants. In modeling neonatal brain injury, Toll-like receptor agonists have often been used to mimic infections and induce inflammation. Using the most common cause of bacteremia in preterm infants, Staphylococcus epidermidis , we present a more clinically relevant neonatal mouse model that addresses the combined effects of bacterial infection together with subsequent hypoxic-ischemic brain insult.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02003-19

Authors: Jacqueline C. Y. Lai, Pernilla Svedin, C. Joakim Ek, Amin Mottahedin, Xiaoyang Wang, Ofer Levy, Andrew Currie, Tobias Strunk, Carina Mallard

Institutions: Boston Children's Hospital, Harvard University, University of Gothenburg, Third Affiliated Hospital of Zhengzhou University, Broad Institute, Murdoch University, The University of Western Australia, King Edward Memorial Hospital

Language: English

Topic: Neonatal and fetal brain pathology

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Estimated APC paid: $1,516

Funders: Torsten Söderbergs Stiftelse, Fondation Leducq, Svenska Forskningsrådet Formas, Stiftelserna Wilhelm och Martina Lundgrens, Hjärnfonden, Åhlén-stiftelsen, STROKE-Riksförbundet

Awards: G1075984740, G1772027490, G43713815, G5035782263, G5270084915, G694449987, G7074128794, G7132548994, G7175888662, G7187505667, G7530466824

OpenAlex ID: W2994638820

FWCI: 2.334

Cites: 63

Cited by: 19

Related to: 10