Work

Cover Picture: Designing a Single Protein‐Chain Reporter for Opioid Detection at Cellular Resolution (Angew. Chem. Int. Ed. 24/2021)

Year: 2021

Type: article

Abstract: A novel class of genetically encoded fluorescent sensors for detecting opioid molecules is reported by Kayla E. Kroning and Wenjing Wang in their Research Article on page 13358. These opioid sensors are called SPOTIT (single-chain protein-based opioid transmission indicator tool). Upon detecting opioids, SPOTIT is activated and generates a persistent green fluorescence mark for image analysis. SPOTIT will potentially be useful for high-throughput screening of opioids in cell cultures and cellular resolution detection of opioids in vivo.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202104889

Authors: Kayla E. Kroning, Wenjing Wang

Institution: University of Michigan

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W3172376890

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