Diterpenoids from Rosmarinus officinalis L. and their nitric oxide inhibitory activity
Year: 2021
Type: article
Abstract: One icetexane diterpenoid, demethylsalvicanol (1) and four abietane diterpenoids, sageone (2), 20‐deoxocarnosol (3), 11,12,20‐trihydroxy‐abieta‐8,11,13‐triene (4), and 7αα‐ethoxyrosmanol (5) were isolated from the n‐hexane layer of the leaves and twigs of Rosmarinus officinalis L. Chemical structures of compounds were identified by ESI‐MS, 1D‐, 2D‐NMR spectra and by comparison of the spectral data in the literature. Compounds 1‐5 were evaluated anti‐inflammatory activity by inhibitory NO production, LPS stimulated on RAW 264.7 cells. At a concentration of 100 μM, compound 4 exhibited inhibitory percentage of 34.7±1.8 %, meanwhile compounds 1‐3 and 5 showed cytotoxic effect. After dilution to concentration of 20 μM, except compound 1 and 2, compounds 3‐5 did not show cytotoxic effect. Their NO inhibitory productions were ranging from 20.5±2.4 % to 26.7±1.9 %. Compounds 1, 3 and 4 have been reported for the first time from the Rosmarinus genus.
Source: Vietnam Journal of Chemistry
Authors: Le Thi Huyen, Le Thi Oanh
Institutions: Vietnam National University, Hanoi, VNU University of Science
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W3172570786