Year: 2020
Type: dissertation
Study designs: Systematic Review, Meta-Analysis
Abstract: Whether non-nutritive sweetened beverages (NSBs) improve cardiometabolic risk factors similar to water in their intended substitution for sugar sweetened beverages (SSBs) is unclear. To assess the effect of 3 prespecified substitutions (NSBs for SSBs, NSBs for water and water for SSBs) on body weight and cardiometabolic risk factors, we undertook a systematic review and network meta-analysis. Fourteen trials (n=1530) predominantly in people with overweight/obesity at risk for or with diabetes were identified. The substitution of NSBs for SSBs improved body weight, BMI, body fat, triglycerides and intrahepatocellular lipids supporting the use of NSBs, as a viable alternative to water, for SSBs. Due to imprecision in the estimate and concerns that NSBs adversely affect glucose tolerance through compositional gut microbiome changes, we provided a rationale, design and baseline characteristics report for the STOP Sugars NOW trial to determine the effect of our 3 prespecified substitutions on gut microbiome and glucose tolerance.
Source: TSpace (University of Toronto)
Author: Néma McGlynn
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3172576543