Work

Inhibiting BRD4 to generate BETter T cell memory

Year: 2021

Type: article

Abstract: BRD4 is a bromodomain-containing protein that binds acetylated histones to regulate transcription. In this issue of JEM, Milner et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202512) show that BRD4 plays a critical role in the effector function of CD8 T cells responding to infection and cancer.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20210877

Authors: Moujtaba Y. Kasmani, Weiguo Cui

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G2672754313, G352720048, Medical Scientist Training Program