Work

What morphology can teach us about renal cell carcinoma clonal evolution

Year: 2020

Type: article

Abstract: While cancer is a clonal process, cumulative evidence suggest that tumors are rather heterogenous and are composed of multiple genetically-distinct subclones that arise at different times and either persist and co-exist, expand and evolve, or are eliminated. A paradigm of tumor heterogeneity is renal cell carcinoma (RCC). By exploiting morphological traits and building upon a framework around three axes (architecture, cytology and the microenvironment), we review recent advances in our understanding of RCC evolution leading to an integrated molecular genetic and morphologic evolutionary model with both prognostic and therapeutic implications. The ability to predict cancer evolution may have profound implications for clinical care and is central to oncology.

Source: Kidney Cancer Journal

DOI: 10.52733/kcj18n3-a1

Authors: Payal Kapur, Alana Christie, Satwik Rajaram, James Brugarolas

Institutions: Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute