The inhibitors of substrate-incorporation in tumor cells. II. Isolation and characterization ofa novel antitumor substance, renastacarcin.
Year: 1977
Type: article
Abstract: A new antitumor substance designated renastacarcin has been isolated from the cultured broth of Streptomyces violascens by means of DEAE-cellulose and Sephadex G-100 column chromatography. The homogeneity of renastacarcin was confirmed by electrophoreses on a polyacrylamide gel and a cellulose acetate membrane as well as by ultracentrifugal analysis. A sedimentation coefficient at 55, 430 rpm was found to be 2.12 S and the molecular weight was calculated to be 34, 500.
Authors: Tetsuo SASAKI, Noboru OTAKE, Akira SHIMAZU, Hiroshi YONEHARA, Akio KOBAYASHI, Hideaki FUKAWA
Institutions: The University of Tokyo, Nisshin Flour Milling Inc. (Japan)
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3174119622