The Mutational Landscape of Double/triple‐hit High‐grade B‐cell Lymphoma With Bcl2 Rearrangement (dh/th‐bcl2) – an Llmpp Project
Year: 2021
Type: article
Abstract: Conclusion:The similarity to FL is suggestive of an evolutionary trajectory through an FL/FL-like common progenitor, where DH/TH-BCL2 diverges from this trajectory by adopting a DZ-like identity.This is supported by near universal DHITsig positivity of both DH/ TH-BCL2 and BL, suggesting this signature more accurately identifies a DZ biology that may be at least partly promoted by MYC rearrangement and mutations in FOXO1 and CCND3.Infrequent mutations promoting immune escape in DH/TH-BCL2 and BL is consistent with a decreased selective pressure due to the "immune cold" nature of the DZ.
Source: Hematological Oncology
DOI: 10.1002/hon.65_2879
Authors: B. J. Collinge, L. K. Hilton, J. Wong, S. Ben‐Neriah, W. Alduaij, C. K. Rushton, G. W. Slack, P. Farinha, T. Miyata‐Takata, J. R. Cook, G. Ott, A. Rosenwald, E. Campo, C. Amador, T. C. Greiner, P. W. Raess, J. Y. Song, G. Inghirami, E. S. Jaffe, D. D. Weisenburger, W. C. Chan, H. Holte, K. Beiske, K. Fu, J. Delabie, S. Pittaluga, A. L. Feldman, L. H. Sehn, K. J. Savage, A. J. Mungall, L. M. Staudt, C. Steidl, L. M. Rimsza, R. D. Morin, D. W. Scott
Institutions: BC Cancer Agency, Simon Fraser University, Niigata University, Cleveland Clinic, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Würzburg, Hospital Clínic de Barcelona, Universitat de Barcelona, University of Nebraska Medical Center, Oregon Health & Science University, City Of Hope National Medical Center, Weill Cornell Medicine, National Cancer Institute, Oslo University Hospital, Roswell Park Comprehensive Cancer Center, University Health Network, University of Toronto, Mayo Clinic, Canada's Michael Smith Genome Sciences Centre, Center for Cancer Research, Mayo Clinic in Arizona
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3174311604