Work

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

Year: 2021

Type: article

Source: Diabetes

DOI: 10.2337/db21-38-or

Authors: ELENI GEORGIADOU, CHARANYA MURALIDHARAN, PAULINE L. CHABOSSEAU, ALEJANDRA TOMAS, THEODOROS STYLIANIDES, CRISTINA LEGIDO-QUIGLEY, NOUR ALSABEEH, CÉLINE CRUCIANI-GUGLIELMACCI, CHRISTOPHE MAGNAN, MARK IBBERSON, ISABELLE LECLERC, AMELIA K. LINNEMANN, YUSUF ALI, TRISTAN RODRIGUEZ, GUY A. RUTTER

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: Medical Research Council

Awards: Investigating the role of immature beta cells in insulin release from the intact islet, Genetic and nutritional control of pancreatic beta cell identity., Roles of GWA genes in controlling pancreatic beta cell function and mass., All-optical deconstruction of the islet wiring patterns underlying insulin secretion in health and disease, Defining the molecular and physiological mechanisms of pancreatic islet dysfunction which lead to type 2 diabetes, Roles of the type 2 diabetes (T2D)-associated gene C2cd4a in regulating glucose homeostasis in the mouse

OpenAlex ID: W3174488704

FWCI:

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Related to: 10