The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium
Year: 2021
Type: article
Abstract: BACKGROUND: Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. OBJECTIVE: To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. METHODS: We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. RESULTS: We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. CONCLUSION: This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk.
Authors: Bashir Dabo, Claudio Pelucchi, Matteo Rota, Harshonnati Jain, Paola Bertuccio, Rossella Bonzi, Domenico Palli, Monica Ferraroni, Zuo-Feng Zhang, Aurora Sanchez-Anguiano, Yen Thi-Hai Pham, Chi Thi-Du Tran, Anh Gia Pham, Guo-Pei Yu, Tin C. Nguyen, Joshua Muscat, Shoichiro Tsugane, Akihisa Hidaka, Gerson S. Hamada, David Zaridze, Dmitry Maximovitch, Manolis Kogevinas, Nerea Fernàndez de Larrea, Stefania Boccia, Roberta Pastorino, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Jesus Vioque, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Paolo Boffetta, Eva Negri, Carlo La Vecchia, Hung N. Luu
Institutions: University of South Florida, University of Milan, University of Brescia, University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center, Vinmec Times City International Hospital, Vinmec Healthcare System, Viet Duc Hospital, Peking University, University of Nevada, Reno, Pennsylvania State University, National Cancer Centre Japan, Russian Cancer Research Center NN Blokhin, Universitat Pompeu Fabra, Municipal Institute for Medical Research, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Hospital del Mar Research Institute, Instituto de Salud Carlos III, Centro Nacional de Epidemiología, Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, Memorial Sloan Kettering Cancer Center, University of West Attica, Harvard University, National and Kapodistrian University of Athens, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Division of Cancer Epidemiology and Genetics, AC Camargo Hospital, Universidade do Porto, Institute of Public Health, University of Porto, Stony Brook University, University of Bologna, University of Pittsburgh, UPMC Health System, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3174546165