Work

Multicomponent syntheses of 5- and 6-membered aromatic heterocycles using group 4–8 transition metal catalysts

Year: 2021

Type: review

Abstract: multicomponent reactions (MCRs) that are catalyzed by group 4-8 transition metals. These MCRs can be categorized based on the substrate components used to generate the cyclized product, as well as on common mechanistic features between the catalyst systems. These particular groupings are intended to highlight mechanistic and strategic similarities between otherwise disparate transition metals and to encourage future work exploring related systems with otherwise-overlooked elements. Importantly, in many cases these early- to mid-transition metal catalysts have been shown to be as effective for heterocycle syntheses as the later (and more commonly implemented) group 9-11 metals.

Source: Chemical Science

DOI: 10.1039/d1sc03037j

Authors: Daniel N. Huh, Yukun Cheng, Connor W. Frye, Dominic T. Egger, Ian A. Tonks

Institutions: University of Minnesota, ETH Zurich

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond