Work

METTL3 induces bone marrow mesenchymal stem cells osteogenic differentiation and migration through facilitating M1 macrophage differentiation.

Year: 2021

Type: article

Abstract: A modification of DUSP14, HDAC5 and Nfam1. Furthermore, the findings showed that expression of HADC5 was downregulated in M1 macrophages with METTL3 knockdown, while the DUSP14 expression had slight change and Nfam1 expression was very low. In contrast, METTL3 overexpression promoted HDAC5 expression, indicating that HDAC5 is the critical target gene of METTL3. Under such a theme, we proposed that METTL3 overexpression might be a new approach of replacement therapy for the treatment of bone repair.

Source: PubMed Central

Authors: Hong Lei, Mingyu He, Xiaoqi He, Guanghui Li, Yang Wang, Yuelin Gao, Gege Yan, Quan Wang, Tao Li, Guoxin Liu, Weijie Du, Ye Yuan, Lei Yang

Institutions: Harbin Medical University, Second Affiliated Hospital of Harbin Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, First Affiliated Hospital of Harbin Medical University

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3175140391

FWCI: 3.279

Cites: 39

Cited by: 42

Related to: 10