A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs).
Year: 2021
Type: article
Abstract: in MSCs profoundly inhibited ectopic bone regeneration and bone matrix mineralization induced by BMP9. Collectively, our results strongly suggest a functional autophagy pathway may play an essential role in regulating osteogenic differentiation induced by BMP9 in MSCs. Thus, restoration of dysregulated autophagic activity in MSCs may be exploited to treat fracture healing, bone defects or osteoporosis.
Source: PubMed Central
Authors: Xia Zhao, Bo Huang, Hao Wang, Na Ni, Fang He, Qing Liu, Deyao Shi, Connie Chen, Piao Zhao, Xi Wang, William Wagstaff, Mikhail Pakvasa, Andrew Blake Tucker, Michael J Lee, Jennifer Moriatis Wolf, Russell R Reid, Kelly Hynes, Jason Strelzow, Sherwin H Ho, Tengbo Yu, Jian Yang, Le Shen, Tong-Chuan He, Yongtao Zhang
Institutions: University of Chicago Medical Center, Affiliated Hospital of Qingdao University, Second Affiliated Hospital of Nanchang University, Chongqing Medical University, The Affiliated Yongchuan Hospital of Chongqing Medical University, Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University, Wuhan Union Hospital, Huazhong University of Science and Technology, Pennsylvania State University
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Medical Scientist National Research Service Award, Citrate Metabonegenic Regulation for the next Generation of Orthopedic Biomaterial Design, A genomewide discovery of chemoresistance-associated noncoding RNAs in human cancers, Cancer Center Support Grant, The Institute for Translational Medicine, Multi-Tissue Craniofacial Engineering using 3D-BMP9-Notch-Synergized Graphene Citrate Composite Scaffolds
OpenAlex ID: W3175564039