Outcomes in patients with newly diagnosed TP53‐mutated acute myeloid leukemia with or without venetoclax‐based therapy
Year: 2021
Type: article
Study design: Observational Study
Abstract: Background Venetoclax (VEN) in combination with a hypomethylating agent (HMA) has become the standard of care for patients aged >75 years and for those not eligible for intensive chemotherapy who have newly diagnosed acute myeloid leukemia (AML). The benefit of VEN‐based therapy in patients who have newly diagnosed AML with mutations in the TP53 gene (TP53mut) over standard therapy is undefined. Methods In this single‐institutional, retrospective analysis, the authors assessed the clinical outcomes of 238 patients with newly diagnosed TP53mut AML and compared the clinical characteristics, response to different therapies, and outcomes of those who received VEN‐based (n = 58) and non–VEN‐based (n = 180) regimens. Results Patients who received VEN‐based regimens were older (aged >65 years: 81% vs 65%; P = .02) and had higher response rates (complete remission, 43% vs 32%; P = .06) than those who received non–VEN‐based regimens. Compared with patients who received non–VEN‐based regimens, no difference in overall survival (median, 6.6 vs 5.7 months; P = .4) or relapse‐free survival (median, 4.7 vs 3.5 months; P = .43) was observed in those who received VEN‐based regimens, regardless of age or intensity of treatment. Conclusions The addition of VEN to standard treatment regimens did not improve outcomes in younger or older patients who had TP53mut AML. These data highlight the need for novel therapies beyond VEN to improve the outcome of patients with TP53mut AML.
Source: Cancer
DOI: 10.1002/cncr.33675
Authors: Sangeetha Venugopal, Mahran Shoukier, Marina Konopleva, Courtney D. Dinardo, Farhad Ravandi, Nicholas J. Short, Michael Andreeff, Gautam Borthakur, Naval Daver, Naveen Pemmaraju, Koji Sasaki, Guillermo Montalban‐Bravo, Kayleigh R. Marx, Sherry Pierce, Uday R. Popat, Elizabeth J. Shpall, Rashmi Kanagal‐Shamanna, Guillermo Garcia‐Manero, Hagop M. Kantarjian, Tapan M. Kadia
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3175636756