Author response: Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
Year: 2021
Type: peer-review
Abstract: Simultaneous inhibition of two distinct kinase targets stimulates bone formation without concurrently increasing bone resorption, therefore representing a promising new treatment strategy for osteoporosis.
Authors: Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein
Institutions: Harvard University, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Hanusch Hospital, Ludwig Boltzmann Institute of Osteology, Leiden University Medical Center, Maine Medical Center Research Institute, Amsterdam UMC Location University of Amsterdam, Broad Institute, Center for Computational and Integrative Biology, Massachusetts General Hospital, Icahn School of Medicine at Mount Sinai, The University of Texas Health Science Center at Houston, Centre National de la Recherche Scientifique, Université Paris Cité, Institut Cochin, Harvard Stem Cell Institute
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W3175729705