Year: 2021
Type: article
Abstract: Protein-coding and noncoding RNAs can be decorated with a wealth of chemical modifications, and such modifications coordinately orchestrate gene expression during normal hematopoietic differentiation and development. Aberrant expression and/or dysfunction of the relevant RNA modification modulators/regulators ("writers," "erasers," and "readers") drive the initiation and progression of hematopoietic malignancies; targeting these dysregulated modulators holds potent therapeutic potential for the treatment of hematopoietic malignancies. In this review, we summarize current progress in the understanding of the biological functions and underlying mechanisms of RNA modifications in normal and malignant hematopoiesis, with a focus on the N6-methyladenosine modification, as well as discuss the therapeutic potential of targeting RNA modifications for the treatment of hematopoietic malignancies, especially acute myeloid leukemia.
Source: Blood
Authors: Ying Qing, Rui Su, Jianjun Chen
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1626310817, The function and underlying mechanism of TET1 in myelodysplastic syndromes, G3114205558, G3165600579, G3237039027, G3780816630, The role and mechanism of FTO in leukemogenesis and drug response, G5154778528, G6456236794, G7887761162, G8967708471, G9000048988, G9000070060, G9000217154, G9000265975
OpenAlex ID: W3176034072