Work

Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures

Year: 2021

Type: conference-paper

Abstract: Nerve damage is a major complication of surgery, causing pain and loss of function. We have identified novel near-infrared nerve-specific fluorophores that provide excellent nerve contrast with the ability to identify buried nerve tissue.

Source: Optics in the Life Sciences

DOI: 10.1364/omp.2021.ow3e.3

Authors: Connor W. Barth, Lei G. Wang, Antonio Montano, Alexander L. Antaris, Alwin Klaassen, Jonathan Sorger, Darcy A. Kerr, Eric R. Henderson, Adam W. G. Alani, Summer L. Gibbs

Institutions: Oregon Health & Science University, Intuitive Surgical (United States), Dartmouth College, Dartmouth–Hitchcock Medical Center, Oregon State University, OHSU Knight Cancer Institute

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: Multimodal Fluorescence- and Imaging-Guided Surgical Navigation: Developing Methods for Subsurface, Indirect Visualization of Cancers Requiring Wide Local Excision, First-in-Human Clinical Translation of a Near-Infrared, Nerve-Specific Fluorophore to Facilitate Tissue-Specific Fluorescence-Guided Surgery

OpenAlex ID: W3176531109

FWCI: 0.314

Cites: 25

Cited by: 3

Related to: 10