Year: 2021
Type: article
Abstract: Multidrug-resistant (MDR) pathogens are responsible for a substantial burden of morbidity and mortality from neonatal sepsis; however, data on these sepsis-related pathogens among hospitalized neonates in China are not well characterized. In this study, a total of 240 strains were isolated from four Women and Children’s hospitals in Southwest China between 2014 and 2019. Of these included pathogens, 104 (43.33%) were gram-positive bacteria, 129 (53.75%) were gram-negative bacteria, and 7 (2.92%) were fungi.Escherichia coli(E. coli, 34.01%) andKlebsiella pneumoniae(K. pneumoniae, 15.35%) were the main pathogen of neonate bacteremia. ST167 were the most prevalent STs inE. coliand ST11 inK. pneumoniae.Our study found thatE. coli(62.71%) was the predominate pathogen of early-onset sepsis, among which 64.86% were MDR. Late-onset sepsis was mainly caused byK. pneumoniae(28.31%) andE. coli(24.78%), with showing that 78.33% of these pathogens were MDR. Notably, the prevalence of EO/LO pathogens were quite different from Indian and south of China. Moreover, we found thatblaCTX-M(42.06%) was most dominant resistant genes with about a third isolates (31.09%) were positive forblaCTX-M-15. All the carbapenem-resistantK. pneumoniaewere positive for NDM-1. Moreover, late-onset sepsis and antibiotic exposure were significantly associated with MDR infection. Emerging multi-resistant pathogens of sepsis posts a serious threat to neonatal outcomes and emphasizes an urgent need to control their further spread.
Authors: Hua Zou, Xiaojiong Jia, Xiao He, Yan Su, Ligang Zhou, Yan Shen, Chenglin Sheng, Ang Liao, Chunli Li, Qiuhong Li
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3177629744