Postnatal depression: drug treatments
Year: 2016
Type: article
Study design: Systematic Review
Abstract: INTRODUCTION: The differentiation between postnatal depression and other types of depression is often unclear, but there are treatment issues in nursing mothers that do not apply in other situations. The point prevalence of major depressive disorder in predominantly high-income countries is about 5% in the first 3 months postpartum. When minor depression is included, it increases to 13%, with a period prevalence rate of 19%. These figures increase further in low-income countries. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of drug treatments for postnatal depression? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2014 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). RESULTS: At this update, searching of electronic databases retrieved 418 studies. After deduplication and removal of conference abstracts, 201 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 139 studies and the further review of 62 full publications. Of the 62 full articles evaluated, one systematic review was updated, and two systematic reviews and one RCT were added at this update. We performed a GRADE evaluation for three PICO combinations. CONCLUSIONS: In this systematic overview, we categorised the efficacy for four interventions based on information about the effectiveness and safety of SSRI antidepressants, antidepressants other than SSRIs, hormones, and St John's Wort.
Source: Europe PMC (PubMed Central)
Author: Michael Craig
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3177779240