Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos
Year: 2021
Type: article
Abstract: STUDY OBJECTIVES: Recent work on US Whites from clinical samples used obstructive sleep apnea (OSA) symptoms to generate phenotypes for individuals with moderate-severe OSA which suggested 3 to 5 symptom classes. However, it is unknown whether similar classes generalize to diverse Hispanics/Latino adults. Therefore, we sought to fill this gap by empirically deriving sleep phenotypes among a large sample of diverse Hispanics/Latinos. METHODS: We used data from The Hispanic Community Health Study/Study of Latinos (HCHS/SOL; 2008-2011), a prospective cohort study designed using a multisite multistage probability sample of adults 18-74 years old. The subpopulation of interest included participants with moderate-severe OSA symptoms (≥15 respiratory event index (REI) events per hour; n = 1,605). We performed latent class analysis for complex survey data using 15 common OSA symptoms (e.g. Epworth Sleepiness Scale) and 4 comorbidities to identify phenotype classes. RESULTS: Average age was 52.4 ± 13.9 years and 34.0% were female. Mean REI was 33.8 ± 22.5 events per hour. Fit statistics and clinical significance suggested that a three-class solution provided the best fit to the data. The three phenotypes were: (1) Minimally Symptomatic (47.7%), (2) Excessive sleepiness (37.1%), and (3) Disturbed Sleep (15.2%). Sensitivity models were consistent with the main proposed solution. CONCLUSIONS: Derived sleep phenotypes among diverse Hispanic/Latinos were consistent with recent findings from the Sleep Apnea Global Interdisciplinary Consortium, but we found notable differences in class prevalence relative to Whites. Further research is needed to link derived sleep phenotypes to health comorbidities in diverse populations.
Source: SLEEP
Institutions: University of California San Diego, Wayne State University, University of Miami, Brigham and Women's Hospital, Harvard University, University of Pittsburgh Medical Center, San Diego State University, Albert Einstein College of Medicine, University of Illinois Chicago, Northwestern University, University of North Carolina at Chapel Hill
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Office of Dietary Supplements, University of Miami, University of North Carolina, Northwestern University, San Diego State University, National Institutes of Health, Albert Einstein College of Medicine, Yeshiva University, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Center on Minority Health and Health Disparities, National Institute on Minority Health and Health Disparities
Awards: G1042216835, G1064233440, G1081972346, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, G1587824183, G1666450717, G1917633662, G2135211244, G2135293100, G2215135821, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2575730562, G2644289446, G2970637568, G3062787641, G3164170294, Phenotypic and Molecular Signatures for Sleep Apnea and Related Morbidities, G3677686024, G3838006641, G3952816605, Study of Latinos Investigation of Neurocognitive Aging 2, G4121762840, Sleep Apnea Phenotypes in Latinos (SLEPT), Hispanic Community Health Study, G4552920371, G4860668542, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G5935820280, G6075306088, G6156511736, G61781031, G6585687856, G6744188800, G7203655167, G7239480477, G7408420985, G8102260223, G820454163, G8840902395, G8904081916, Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's Biomarkers, San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR), Sleep in Neurocognitive Aging and Alzheimers Research (SANAR), G974369616
OpenAlex ID: W3178153148