Work

Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells

Year: 2021

Type: article

Abstract: FC ≥ 1). Polymyxins perturbed key metabolic pathways that maintain cellular redox balance, mitochondrial β-oxidation, and membrane lipid biogenesis. These mechanistic findings may assist in developing new pharmacokinetic/pharmacodynamic strategies to attenuate the pulmonary toxicities of inhaled polymyxins and in the discovery of new-generation polymyxins.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00835-21

Authors: Maizbha U. Ahmed, Mohammad A. K. Azad, Mengyao Li, Darren J. Creek, Meiling Han, Fanfan Zhou, Kim Chan, Qi Tony Zhou, Tony Velkov, Jian Li

Institutions: Monash University, The University of Sydney, Purdue University West Lafayette, The University of Melbourne

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Department of Health and Aged Care, Australian Government, National Health and Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach, Optimising inhaled polymyxins as a vital therapy for pulmonary infections: A novel biochemical, molecular imaging and systems pharmacology approach, G6216839016, Advancing innovative therapies against pandrug-resistant Gram-negative superbugs

OpenAlex ID: W3179733527

FWCI: 0.882

Cites: 59

Cited by: 9

Related to: 10