Work

Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity.

Year: 2021

Type: article

Abstract: levels. Transmission electron microscopy revealed HNK-induced changes in mitochondrial morphology. HNK decreased the activity of Glutathione Peroxidase 4 (GPX4) but did not affect system Xc-. Thus, our datas indicated that HNK can induce ferroptosis in CC cells by reducing the activity of GPX4. As a potential therapeutic drug, HNK showed good anticancer effects through diverse signal transduction mechanisms and multiple pathways.

Source: PubMed Central

Authors: Cao Guo, Ping Liu, Ganlu Deng, Ying Han, Yihong Chen, Changjing Cai, Hong Shen, Gongping Deng, Shan Zeng

Institutions: Central South University, Xiangya Hospital Central South University, First Affiliated Hospital of GuangXi Medical University, Hainan General Hospital, Hainan Medical University

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3180167308

FWCI: 4.213

Cites: 41

Cited by: 64

Related to: 10