BMI1 activates P-glycoprotein via transcription repression of miR-3682-3p and enhances chemoresistance of bladder cancer cell
Year: 2021
Type: article
Abstract: (ATP binding cassette subfamily B member 1) gene. Moreover, suppression of P-glycoprotein by miR-3682-3p mimics or its inhibitor XR-9576, could significantly reverse chemoresistance of T24/DDP&GEM cells. These results provided a novel insight into a portion of the mechanism underlying BMI1-mediated chemoresistance in bladder cancer.
Source: Aging
Authors: Ming-Kun Chen, Jun-Hao Zhou, Peng Wang, Yun-lin Ye, Yang Liu, Jia-Wei Zhou, Zi-Jian Chen, Jian-Kun Yang, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qi-Zhao Zhou, Kang-Yi Xue, Wen-Bin Guo, Ming Xia, Ji-Ming Bao, Cheng Yang, Hai-Feng Duan, Hong-Yi Wang, Zhi-Peng Huang, Zi-Ke Qin, Cun-Dong Liu
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3180776851