Identification of simple arylfluorosulfates as potent agents against resistant bacteria
Year: 2021
Type: article
Abstract: Significance Excessive use of antibiotics for patient therapy and livestock results in the selection of pathogenic bacteria resistant to multiple drugs. The spread of multidrug-resistant bacteria into the community is associated with increased morbidity, mortality, and financial burden of health care. We constructed a library of SuFEx-derived arylfluorosulfates that demonstrated potent activities in combating multidrug-resistant bacteria both in vitro and in vivo. Significantly, these arylfluorosulfate analogs show enhanced potency to disrupt bacterial biofilm as well as kill persisters and have a synergistic effect with clinical bactericidal drugs. This study suggests that arylfluorosulfates derived from SuFEx-based modification of phenols could serve as a convenient strategy to search for bactericidal candidates.
Institutions: Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Scripps Research Institute, Guangdong Laboratory Animals Monitoring Institute
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3180972189