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Mouse Antibodies with Activity Against the SARS-CoV-2 D614G and B.1.351 Variants

Year: 2021

Type: preprint

Abstract: With the rapid spread of SARS-CoV-2 variants, including those that are resistant to antibodies authorized for emergency use, it is apparent that new antibodies may be needed to effectively protect patients against more severe disease. Differences between the murine and human antibody repertoires may allow for the isolation of murine monoclonal antibodies that recognize a different or broader range of SARS-CoV-2 variants than the human antibodies that have been characterized so far. We describe mouse antibodies B13 and O24 that demonstrate neutralizing potency against SARS-CoV-2 Wuhan (D614G) and B.1.351 variants. Such murine antibodies may have advantages in protecting against severe symptoms when individuals are exposed to new SARS-CoV-2 variants.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2021.07.05.451203

Authors: Larisa Troitskaya, Nelson Lap Shun Chan, Brendon Frank, Daniel J. Capon, Brian A. Zabel, Xiaomei Ge, Dan Luo, Rachel Martinelli, Jing Jin, Graham Simmons

Institutions: LakePharma (United States), Vitalant Research Institute, University of California, San Francisco

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3181503749

Cites: 14

Cited by: 2

Related to: 10