Work

MAGUKs are essential, but redundant, in long-term potentiation

Year: 2021

Type: article

Abstract: This study presents evidence that the MAGUK family of synaptic scaffolding proteins plays an essential, but redundant, role in long-term potentiation (LTP). The action of PSD-95, but not that of SAP102, requires the binding to the transsynaptic adhesion protein ADAM22, which is required for nanocolumn stabilization. Based on these and previous results, we propose a two-step process in the recruitment of AMPARs during LTP. First, AMPARs, via TARPs, bind to exposed PSD-95 in the PSD. This alone is not adequate to enhance synaptic transmission. Second, the AMPAR/TARP/PSD-95 complex is stabilized in the nanocolumn by binding to ADAM22. A second, ADAM22-independent pathway is proposed for SAP102.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2107585118

Authors: Xiumin Chen, Yuko Fukata, Masaki Fukata, Roger A. Nicoll

Institutions: University of California, San Francisco, National Institutes of Natural Sciences, The Graduate University for Advanced Studies, SOKENDAI, National Institute for Physiological Sciences

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: Japan Society for the Promotion of Science, National Institute of Mental Health