Year: 2021
Type: review
Abstract: Many broadly neutralizing antibodies (bnAbs) targeting the HIV-1 envelope glycoprotein are being assessed in clinical trials as strategies for HIV-1 prevention, treatment, and antiretroviral-free remission. BnAbs can neutralize HIV-1 and target infected cells for elimination. Concerns about HIV-1 resistance to single bnAbs have led to studies of bnAb combinations with non-overlapping resistance profiles. This review focuses on the potential for bnAbs to induce HIV-1 remission, either alone or in combination with latency reversing agents, therapeutic vaccines or other novel therapeutics. Key topics include preliminary activity of bnAbs in preclinical models and in human studies of HIV-1 remission, clinical trial designs, and antibody design strategies to optimize pharmacokinetics, coverage of rebound-competent virus, and enhancement of cellular immune functions.
Source: Frontiers in Immunology
Authors: Denise C. Hsu, John W. Mellors, Sandhya Vasan
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G1234541941, Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure, G1546679804, G1589278233, ADDRESSING THE THREATS OF HIV AND EMERGING INFECTIOUS DISEASE TO THE MILITARY AND GLOBAL COMMUNITY THROUGH INNOVATIVE RESEARCH, G2271303644, G2415337126, G2507544392, IMMUNE CORRELATE + GUIDED DESIGN OF MONOCIONAL THERAPEUTICS FOR HIV REMISSION, G285461174, G3079951032, G4119534169, G4573400019, Combined Immunologic Approaches to Cure HIV-1, G4689185066, G5850682332, G6063997168, G632435055, G633733221, G6581139398, G6812101401, G8093122957, G8166743225, US MILITARY HIV RESEARCH, US MILITARY HUMAN IMMONODEFIECIENCY VIRUS (HIV) RESEARCH PROGRAM, G9000280138, The Military HIV Research Program (MHRP) Clinical Trial Unit, AIDS Clinical Trial Group Laboratory Center, Pitt-Ohio State Clinical Trials Unit, Native-like Envelope Trimer Therapeutic Vaccination for Induction of Broadly Neutralizing Antibodies to Facilitate HIV Functional Cure
OpenAlex ID: W3182286300