Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer's disease
Year: 2021
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Cardiorespiratory fitness (CRF) may mitigate Alzheimer's disease (AD) progression. This study examined the longitudinal associations of CRF with brain atrophy and cognitive decline in a late-middle-aged cohort of adults at risk for AD. METHODS: One hundred ten cognitively unimpaired adults (66% female, mean age at baseline 64.2 ± 5.7 years) completed a baseline graded treadmill exercise test, two brain magnetic resonance imaging scans (over 4.67 ± 1.17 years), and two to three cognitive assessments (over 3.26 ± 1.02 years). Linear mixed effects models examined the longitudinal associations adjusted for covariates. RESULTS: = .426). Exploratory analyses suggested these effects may be stronger among apolipoprotein E ε4 carriers. DISCUSSION: CRF is a modifiable physiological attribute that may be targeted during the preclinical phase of AD in effort to delay disease progression, perhaps most effectively among those with genetic risk.
DOI: 10.1002/dad2.12212
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
Awards: Longitudinal Assessment of Physical Activity, Cerebral Glucose Metabolism, and Cognitive Function in an At-risk Cohort, Institutional Clinical and Translational Science Award (UW-Madison)(UL1), Wisconsin Registry for Alzheimer's Prevention, Early detection of asymptomatic middle-age adults at risk for AD, Genetic and Lifestyle Determinants of Cognitive Resilience in Midlife, The Longitudinal Course of Imaging Biomarkers in People At Risk for Alzheimer’s Disease, Wisconsin Registry for Alzheimer's Prevention, Wisconsin Alzheimer's Disease Research Center, Research Training in Age-Related Cognitive Disorders
OpenAlex ID: W3182684464