Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation
Year: 2021
Type: article
Abstract: Interorgan signaling is a critical feature of human biology and physiology, yet has remained difficult to study due to the lack of in vitro models. Here, we demonstrate that physical coupling of ex vivo human intestine and liver epithelial organoid cultures recapitulates in vivo interorgan bile acid signaling. These results suggest that coupling of multiple organoid systems provides new models to investigate interorgan communication and advances our knowledge of human physiological and pathophysiological processes.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Advancing Translational Sciences
Awards: G2106694058, G3175189153, A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity, G4449415799, Proteomics and Metabolomics Core Facility, G5437170232, G8464401390, Gulf Coast Center for Precision Environmental Health, Texas Medical Center Digestive Diseases Center, Baylor College of Medicine Cancer Center - Cancer Center Support Grant
OpenAlex ID: W3183261111