Obesity in Children with Acute Promyelocytic Leukemia: What is its Incidence and Prognostic Significance?
Year: 2021
Type: preprint
Abstract: Objective: To compare outcomes data of obese and non-obese pediatric patients with acute promyelocytic leukemia from the Cancer and Leukemia Group B trial C9710 and the Children’s Oncology Group trial AAML0631. Methods: Data including demographics, adverse events, overall survival and event free survival was analyzed, with a focus on mortality in obese patients. Results: The incidence of obesity was 34% on C9710 and 35% on AAML0631. There was significantly lower overall survival in the obese population on AAML0631. Thirteen patients died during therapy or in follow up; seven of these occurred during induction. Conclusion: The incidence of obesity is higher in patients with APL compared to the general population. The presence and degree of obesity can influence OS on the most current treatment regimen. This implies the need for close management of obese patients at diagnosis as well as reinforces the need for further research on obesity driven APL
Institutions: Goryeb Children's Hospital, AbbVie (United States), Northwestern University, University of Southern California, Children's Oncology Group, Children's Oncology Group, Atrium Health Wake Forest Baptist, Wake Forest Baptist Comprehensive Cancer Center, St. Jude Children's Research Hospital, University of Chicago, Morristown Medical Center, University of Alabama at Birmingham, Columbia University, UCSF Benioff Children's Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W3183406441