Complex physical properties of a self-organizing biological system
Year: 2021
Type: preprint
Abstract: The physical interpretation of the functioning of the adaptive immune system, which maintains host integrity by accelerated protein evolution, provides a unique opportunity to observe and define a self-organizing system in its entirety. Using a configuration space model of immune function, wherein directed chemical potentials of the system components create a vector space of interactions, the architecture of self-organization suggests that a fractal scale-free network distributes energy through the system. In the physical sense the adaptive immune system adjusts the chemical potential of all available molecules by tuning the chemical potential and organizing the network hierarchy of its sensor-effector molecules, antibodies. Coupling of free energy sensors and effectors allows the system to regulate its composition, while network organization helps minimize chemical potentials and maximize diversity. Overall, a stochastic model of adaptive immunity may provide a universal physical model for self-organizing systems with power law distribution of thermodynamic activities.
Source: arXiv (Cornell University)
Author: József Prechl
Language: English
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3183979830