Year: 2021
Type: review
Abstract: This review covers recent findings in the genomics of obsessive-compulsive disorder (OCD), obsessive-compulsive symptoms, and related traits from a dimensional perspective. We focus on discoveries stemming from technical and methodological advances of the past five years and present a synthesis of human genomics research on OCD. On balance, reviewed studies demonstrate that OCD is a dimensional trait with a highly polygenic architecture and genetic correlations to multiple, often comorbid psychiatric phenotypes. We discuss the phenotypic and genetic findings of these studies in the context of the dimensional framework, relying on a continuous phenotype definition, and contrast these observations with discoveries based on a categorical diagnostic framework, relying on a dichotomous case/control definition. Finally, we highlight gaps in knowledge and new directions for OCD genetics research.
Source: Translational Psychiatry
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $4,380
Awards: G1026292475, G1069064389, Integrating Common and Rare Variation to Discover Genes Associated with Tourette Syndrome, G2368233345, Mental health and chronic disease: A psycheMERGE investigation into the shared biology underlying psychiatric disorders and their physical comorbidities, G5366963641, G5418963949, G6404433027, Large-Scale Collaborative Genetic and Epigenetic Studies of Tourette Syndrome, Discovering Biology for Neuropsychiatric Diseases Through Omics Studies on Comorbidities, G8692035495
OpenAlex ID: W3184192589