Year: 2021
Type: review
Abstract: Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, we describe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formation as well as in non-hematopoietic tissues and tumor cells. Although the central framework of these pathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineage differences. We summarize the current state of research in this field, highlight the novel members of EPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroid and non-erythroid cells.
DOI: 10.3390/ijms22147682
Authors: Zuzana Tóthová, Martina Šemeláková, Zuzana Solárová, Jana Tomc, Nataša Debeljak, Peter Solár
Institutions: University of Pavol Jozef Šafárik, University of Ljubljana
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,160
Award: G2993185900
OpenAlex ID: W3184351883