Work

Pew 2 : Open-Source Imaging Software for Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry

Year: 2021

Type: article

Abstract: Open-sourced software is a key component of the mass spectrometry imaging field, where transparency in data processing is vital. Imaging of trace elements and immunohistochemically labeled biomolecules in tissue sections is typically performed using laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS). However, efficient and facile processing of images is hampered by a lack of verifiable and user-friendly software that supports multiple LA-ICP-MS platforms. In this technical note, we introduce Pew 2, a LA-ICP-MS specific and feature-rich open-source image processing software that is compatible with common ICP-MS vendors. Pew 2 is designed to be fast and easy to use and adheres to modern visualization philosophies to maximize productivity and to minimize data interpretation errors and image anomalies.

Source: Analytical Chemistry

DOI: 10.1021/acs.analchem.1c02138

Authors: Thomas E. Lockwood, Mika T. Westerhausen, Philip A. Doble

Institution: University of Technology Sydney

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Australian Government, Australian Research Council

Award: Aptamer imaging mass spectrometry for biomarker quantification