Work

One-Pot Synthesis of α-Alkyl Styrene Derivatives

Year: 2021

Type: article

Abstract: There is a significant need to develop more rapid and efficient routes to styrene derivatives, since they are extensively used in polymer sciences. This manuscript reports a one-pot synthesis of an array of α-alkyl styrene derivatives from readily available natural products (i.e., estragole and safrole). This method is regioselective, producing a rearranged adduct, under transition metal-free conditions. This methodology has broad nucleophile scope, even tolerating sterically hindered nucleophiles; it is general for carbon, nitrogen, oxygen, and sulfur nucleophiles.

Source: ACS Omega

DOI: 10.1021/acsomega.1c02801

Authors: Olatunji S. Ojo, Alejandro Bugarin

Institutions: The University of Texas at Arlington, Florida Gulf Coast University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,250