Work

Cytokine profiles in children with acute intussusception in South Africa

Year: 2021

Type: article

Abstract: Serum specimens of children hospitalized with acute intussusception (IS; n = 407) were analyzed for various pro- and anti-inflammatory cytokines to identify host markers specifically for IS compared to other surgical conditions (n = 235) or acute gastroenteritis (AGE; n = 68) in a cross-sectional study design. We showed that children with IS had elevated levels of pro-inflammatory cytokines IFN-γ, TNF-α, MIP-1β, IL-1β, IL-2, IL-6, IL-7, IL-8, and IL-17 as well as anti-inflammatory cytokines IL-1RA, IL-4, IL-5, and IL-13 compared to those admitted with surgical conditions or AGE symptoms, indicating these cytokines as markers for IS. In addition, we showed an increase in C-reactive protein (CRP) levels in children with IS. This study is the first to show a broad cytokine profile and identify cytokine markers in children with IS.

Source: Cytokine

DOI: 10.1016/j.cyto.2021.155639

Authors: Theresa K. Bessey, Umesh D. Parashar, Jacqueline E. Tate, Shabir A. Madhi, Baoming Jiang, Michelle J. Groome

Institutions: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, South African Medical Research Council, University of the Witwatersrand

Language: English

Topic: Gastrointestinal disorders and treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,400