Work

Cortical spheroids display oscillatory network dynamics

Year: 2021

Type: article

Abstract: 3-D spheroid cultures contain networks that develop by 9 days and develop increasingly complex network activity patterns as they mature. We demonstrate, for the first time, that spheroids exhibit network activity similar to in vivo network events.

Source: Lab on a Chip

DOI: 10.1039/d1lc00737h

Authors: Jessica L. Sevetson, Brian Theyel, Diane Hoffman-Kim

Institution: Brown University

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: Brown University, Office of Naval Research, National Institute of Environmental Health Sciences

Awards: G5543469522, Human 3D Microtissues for Toxicity Testing via Integrated Imaging, Molecular and Functional Analyses