Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection
Year: 2021
Type: article
Abstract: HIV preferentially infects α4β7+ CD4 T cells, forming latent reservoirs that contribute to HIV persistence during antiretroviral therapy. However, the properties of α4β7+ CD4 T cells in blood and mucosal compartments remain understudied. Employing two distinct models of HIV infection, HIV‐infected humans and simian–human immunodeficiency virus (SHIV)‐infected rhesus macaques, we show that α4β7+ CD4 T cells in blood are enriched for genes regulating cell cycle progression and cellular metabolism. Unlike their circulating counterparts, rectal α4β7+ CD4 T cells exhibited a core tissue‐residency gene expression program. These features were conserved across primate species, indicating that the environment influences memory T‐cell transcriptional networks. Our findings provide an important molecular foundation for understanding the role of α4β7 in HIV infection.
Source: FEBS Letters
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: Targeting CD4 TFH cells to enhance HIV vaccine-induced humoral immunity, G1608622235, Emory WIHS CRS - Longitudinal Cohort, G4657447082, Resource fo Nonhuman Primate Cell Depleting Antibodies, Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibility, Center for AIDS Research at Emory University, Role of vaginal microbiome and metabolome in HIV vaccine efficacy
OpenAlex ID: W3185807125