The Impact of Persistent Irritability on the Medication Treatment of Paediatric Attention Deficit Hyperactivity Disorder
Year: 2021
Type: article
Abstract: This study compares the efficacy and tolerability of central nervous system (CNS) stimulants in children with attention deficit hyperactivity disorder (ADHD) with and without prominent irritability (IRR) over the course of 30 months. This is a secondary analysis of a study examining growth patterns in medication naïve children with ADHD subsequently treated with CNS stimulants (predominantly OROS-Methylphenidate, up to 54 mg per day) for 30 months. Participants had to meet full diagnostic criteria for ADHD and been treated with CNS stimulants for under 30 days. Children were classified as IRR if they were rated as pretty much or very much on either of the “often angry” or easily annoyed” items plus “lose temper,” items of the Disruptive Behavior Disorders Rating Scale (DBDRS). Structured ratings of ADHD symptoms, impairment, side effects, and symptoms of oppositional defiant disorder (ODD) were collected every 2–12 weeks for the duration of the study. Medication use was measured by pill count and parent report. The IRR group comprised 28% of all participants. The IRR group had significantly higher levels of ADHD and ODD symptoms, impairment, and side effects ratings at baseline. In the IRR group, ODD symptoms, emotional lability, and impairment significantly decreased for participants with higher medication use. Total side effects increased for non-IRR participants with higher medication use. Emotional side effects decreased for IRR participants with higher medication use. Central nervous system stimulants were a tolerable and efficacious treatment in treatment naïve youth with ADHD with irritability. Clinical Trials Registration: NCT01109849
Source: Frontiers in Psychiatry
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: Examining Tolerance to CNS Stimulants in ADD, Neural correlates of adult outcomes of childhood ADHD: Affect, reward and control, G3489202886, A Novel Approach to Stimulant-Induced Weight Suppression and its Impact on Growth, Designing a Novel Behavioral Treatment Protocol for Children Characterized by Con, Intervention for Teens with ADHD and Substance Use, Identifying Children and Teens at Risk for Early Onset Alcohol Use: An Innovative Application of Machine Learning Algorithms to Prevention, A Novel Multimodal Intervention for Children with ADHD and Impaired Mood, Adaptive Response to Intervention (RTI) for Students with ADHD, Research training in drug abuse prevention: closing the research-practice gap
OpenAlex ID: W3185931668