Year: 2021
Type: preprint
Study design: Observational Study
Abstract: Background Herbal and Dietary Supplements (HDS) are capable of causing liver injury, however, the extent of HDS-induced liver injury compared to western medication (WM)-induced liver injury has not been well studied. Methods This was a three-year, retrospective study from 308 centers across Mainland China. 3,877 patients with liver injury due to HDS and 3,796 patients with liver injury due to WM were analyzed. Demographic and clinical characteristics, implicated agents, and severity of liver injury were analyzed using descriptive statistics. Results The HDS group was older (average age 47.65 ± 14.8 years) and had more females (57.92%). The latency to onset of liver injury was greater in the HDS group than in the WM group (41 vs. 35 days, P < 0.0001). The median levels of serum aspertate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) at injury detection and at peak were significantly higher in the HDS group (P < 0 .0001). The mortality and incidence of acute liver failure (ALF) did not differ significantly between groups (0.59% vs. 0.76%, P = 0.3643; 2.31% vs. 2.13%, P = 0.6253). In patients without pre-existing liver diseases, the frequency of chronic DILI was higher in the HDS group (15.26% vs. 11.13%, P < 0 .0001). Conclusion Compared to WM-DILI, HDS-DILI is more common in older individuals and women, and has a longer latency period. HDS seems to cause more severe clinical manifestations, yet it does not increase the risk of fatal clinical outcomes. Further regulations on the use of HDS are needed.
Source: Research Square
Authors: Xinyu Liu, Rongtao Lai, jieting tang, Yulin Hu, Yang Ding, Guruprasad P. Aithal, Raúl J Andrade, Paul B. Watkins, Tao Shen, Yueping Jiang, Yanyan Yu, Jiyao Wang, Peng Hu, Weihong Sha, Lei Li, Shiwu Ma, Jing Li, Chenghai Liu, Jinjun Chen, Qing Mao, Qinghua Lu, Haixing Jiang, Qingling Xu, Hong Yuan, Yufang LI, Li Shi, Liangming Liu, Kewei Sun, Xi’an Han, Wei Zhong, Jun Chen, Chengwei Chen, Yimin Mao
Institutions: Central South University, Third Xiangya Hospital, Shanghai Jiao Tong University, Ruijin Hospital, China Medical University, Nottingham University Hospitals NHS Trust, Universidad de Málaga, North Carolina Central University, Peking University, Qingdao University, Peking University First Hospital, Zhongshan Hospital, Chongqing Medical University, Guangdong Provincial People's Hospital, First Hospital of China Medical University, Chinese People's Liberation Army, Huaian First People’s Hospital, Shanghai University of Traditional Chinese Medicine, Nanfang Hospital, ShenZhen People’s Hospital, Southern Medical University, Army Medical University, Guangxi Medical University, Fujian Medical University, Lanzhou University, Ningxia Medical University, Songjiang District Central Hospital, State University of Medan, Renji Hospital
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3186473085