Changes and significance of serum FGF21 in children with primary nephrotic syndrome and chronic renal failure.
Year: 2021
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The aim of the study was to investigate the changes and significance of serum fibroblast growth factor 21 (FGF21) in children with primary nephrotic syndrome (PNS) and chronic renal failure. METHODS: Pediatric patients with active PNS and normal renal function (the nephrotic syndrome group), pediatric patients with chronic renal failure (the renal failure group), and children who had healthy physical examinations (the control group) were included. The serum levels of FGF21, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were measured by enzyme-linked immunosorbent assay (ELISA), and the serum albumin and 24 h urine protein were measured in the PNS group. RESULTS: > 0.05). CONCLUSION: The level of serum FGF21 may be correlated with the occurrence and development of nephrosis in children. The higher the level of serum FGF21, the more serious the renal injury.
Source: PubMed
Authors: Nian Wei, Zhi-Qiang Guo, Fang Yang
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3186995444