Work

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across

Year: 2021

Type: review

Source: Advanced Drug Delivery Reviews

DOI: 10.1016/j.addr.2021.113900

Authors: An-Katrien Minnaert, Helena Vanluchene, Rein Verbeke, Ine Lentacker, Stefaan C. De Smedt, Koen Raemdonck, Niek N. Sanders, Katrien Remaut

Institutions: Ghent University, Cancer Research Institute Ghent

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Commission, Fonds Wetenschappelijk Onderzoek, Universiteit Gent, Vlaamse regering

Awards: G434337789, The barrier role of the vitreoretinal interface toward intravitreal injected proteins, viruses and siRNA nanoparticles: ex vivo bovine screening models and siRNA nanoparticle design., mRNA Lipid nanoparticles co-loaded with alpha-Galactosylceramide as a universal influenza vaccine platform, G7017582607, Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis, Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.

OpenAlex ID: W3187029494

FWCI: 2.09

Cites: 253

Cited by: 156

Related to: 10