Extract and Component-Specific Allergen Recognition Patterns in Canadian Children: Insights into Preschool Asthma and Nut Allergy
Year: 2020
Type: dissertation
Study design: Observational Study
Abstract: The early presence and diversity of allergic sensitization is a risk factor for the development of asthma and a diagnostic marker for allergy. Assessing IgE sensitization at the allergen extract and protein component level may increase specificity by providing insights into allergen protein families involved and thereby improve predictions of clinical relevance of sensitization. Using a comprehensive multiplex IgE test, we characterized sensitization profiles in a cohort of preschool asthmatics and identified potential allergen biomarkers (Ara h 1, 2, 3, 6, Fel d 1, and Can f 1) that were associated with more severe asthma. We also identified allergen components that may be able to improve specificity of peanut and tree nut allergy diagnosis in this pediatric population (Ara h 1, 2, 6, Cor a 14, Jug r 1, Ana o 3). Lastly, we generated models that allow the comparison and conversion of specific IgE-levels measured using different testing platforms.
Source: TSpace (University of Toronto)
Author: Jennifer A. Hoang
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3187057885