Associations between childhood victimization, inflammatory biomarkers and psychotic phenomena in adolescence: A longitudinal cohort study
Year: 2021
Type: article
Study design: Observational Study
Abstract: Exposure to victimization in childhood has been linked to the development of psychosis. However, little is known about how childhood victimization is translated into biological risk for psychosis. One possibility is via increased inflammation. This study aimed to investigate the association between childhood victimization, psychotic experiences (PEs) in adolescence and inflammatory markers using data from a general population cohort. Participants were 1,419 British-born children followed from birth to age 18 years as part of the Environmental Risk Longitudinal Twin Study. Childhood victimization was measured prospectively using multiple sources from birth to age 12 years. PEs were assessed during private interviews with participants at age 18 years for the period since age 12. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble urokinase plasminogen activator receptor (suPAR) levels were measured from plasma samples collected from participants at 18 years. Young people with both PEs and childhood victimization were more likely to belong to a group with elevated suPAR, CRP and IL-6 levels at 18 years of age (OR = 3.34, 95% CI 1.69-6.59, p = 0.001) than those with no childhood victimization and without PEs. However, this association was attenuated when adjusted for other risk factors for elevated inflammation at age 18 (OR = 1.94, 95% CI 0.94-4.04, p = 0.075). In contrast, presence of PEs without childhood victimization was not significantly associated with age-18 inflammatory markers and neither was childhood victimization without PEs (all p's greater than 0.05). The current study highlights that inflammatory dysregulation is mostly present in adolescents reporting PEs who also experienced childhood victimization, though this seemed to be largely due to concurrent inflammation-related risk factors.
Source: Brain Behavior and Immunity
Language: English
Topic: Child Abuse and Trauma
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,620
Funders: South London and Maudsley NHS Foundation Trust, National Institute for Health and Care Research, Department of Health and Social Care, Nuffield Foundation, Academy of Medical Sciences, King's College London, Lundbeckfonden, Jacobs Foundation, H. Lundbeck A/S, NIHR Maudsley Biomedical Research Centre, Medical Research Council, Economic and Social Research Council, National Institute of Child Health and Human Development
Awards: G1193229881, G2039281854, G4036427723, G4042419365, G4154018034, G4184501341, G4919021182, G5701737369, G6637449936, G6671708061, Mental Health Leadership Fellow - The impact of social relationships in the 21st century on mental health and wellbeing, Centre for Society and Mental Health, G7599878082, G7883804441
OpenAlex ID: W3188112123