Work

Novel Non-Opioid Based Therapeutics for Chronic Neuropathic Pain.

Year: 2021

Type: article

Abstract: Chronic neuropathic pain is currently a major health issue in U.S. complicated by the lack of non-opioid analgesic alternatives. Our investigations led to the discovery of major signaling pathways involved in the transition of acute to chronic neuropathic pain and the identification of several targets for therapeutic intervention. Our translational approach has facilitated the advancement of novel medicines for chronic neuropathic pain that are in advanced clinical development and clinical trials.

Source: PubMed

Authors: Timothy M Doyle, Kathryn Braden, Caron M Harada, Fatma Mufti, Rachel M Schafer, Daniela Salvemini

Institution: Saint Louis University

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Drug Abuse, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Role of peroxynitrite in morphine hyperalgesia and tolerance, Targeting the relief of chronic pain with orally active peroxynitrite decompositi, A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathy, Role of opioid-induced S1P/S1PR1 axis activation in neuroinflammatory reponses, Preserving opioid analgesia using a novel adenosinergic approach, Role of ceramide in morphine hyperalgesia and tolerance, Pharmacological Sciences Training Grant

OpenAlex ID: W3188134142

FWCI: 0.152

Cites: 82

Cited by: 1

Related to: 10