Mp08-16 Low Pressure Voiding Induced by Pudendal Nerve Stimulation and Block Using Lead Electrodes in Cats
Year: 2021
Type: article
Abstract: sphincter, as well as bladder pressure data were collected, first under isovolumetric bladder conditions and later during filling cystometries.RESULTS: Epidural SCS through many electrodes was able to elicit functional changes in the bladder and urethra.We also identified bipolar electrode pairs that evoked a frequency-dependent effect.Stimulation at 3 Hz stimulation evoked a continence reflex, while the same electrodes evoked a voiding reflex when the stimulation frequency was changed to 33 Hz.Inhibition through 3 Hz stimulation was particularly robust and resulted in abolishing all non-voiding contractions (NVCs) and decreasing the bladder pressure to its baseline value.Voiding under 33 Hz was incomplete and varied between 20-50% of the infused volume.In 3 animals, an acute spinalization at T10 abolished all 33 Hz-evoked responses suggesting that this neural circuit requires an intact spino-bulbo-spinal reflex.The 3 Hz continence reflex remained unaffected by spinalization suggesting a local reflex in the lumbosacral spinal cord.CONCLUSIONS: HR-SCS can selectively evoke continence and micturition reflexes through a unique frequency-dependent effect.
Source: The Journal of Urology
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3189244531