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Atherosclerotic Renovascular Disease: A KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference

Year: 2021
Type: article
Abstract: The diagnosis and management of atherosclerotic renovascular disease (ARVD) is complex and controversial. Despite evidence from the ASTRAL (2009) and CORAL (2013) randomized controlled trials showing that percutaneous renal artery revascularization did not improve major outcomes compared with best medical therapy alone over 3-5 years, several areas of uncertainty remain. Medical therapy, including statin and antihypertensive medications, has evolved in recent years, and the use of renin-angiotensin-aldosterone system blockers is now considered the primary means to treat hypertension in the setting of ARVD. However, the criteria to identify kidneys with renal artery stenosis that have potentially salvageable function are evolving. There are also data suggesting that certain high-risk populations with specific clinical manifestations may benefit from revascularization. Here, we provide an overview of the epidemiology, diagnosis, and treatment of ARVD based on consensus recommendations from a panel of physician experts who attended the recent KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference on central and peripheral arterial diseases in chronic kidney disease. Most focus is provided for contentious issues, and we also outline aspects of investigation and management of ARVD that require further research.
DOI: 10.1053/j.ajkd.2021.06.025
Authors: Caitlin W. Hicks, Timothy W.I. Clark, Christopher J. Cooper, Áine M. de Bhailís, Marco De Carlo, Darren Green, Jolanta Małyszko, Marius Miglinas, Stephen C. Textor, Charles A. Herzog, Kirsten L. Johansen, Holger Reinecke, Philip A. Kalra
Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Pennsylvania, University of Toledo, Salford Royal Hospital, Azienda Ospedaliera Universitaria Pisana, Medical University of Warsaw, Vilnius University, Vilnius University Hospital Santariskiu Klinikos, Mayo Clinic, University of Minnesota, Hennepin Healthcare Research Institute, University Hospital Münster, Salford Royal NHS Foundation Trust
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,200
OpenAlex ID: W3190173874
FWCI: 5.37
Cites: 110
Cited by: 81
Related to: 10