Mp60-05 Molecular Profiling of Prostate Cancer Reveals Increased Inflammatory Markers and Poor Clinical Outcomes in African American Compared to European American Men
Year: 2021
Type: article
Abstract: AUC, specificity, NPV and PPV compared to total PSA, % free PSA, and % free PSA (total PSA 4-10 ng/mL).The AUC, sensitivity and specificity of IsoPSA were stable and durable in both biopsy naïve and prior negative biopsy cohorts.The diagnostic accuracy of IsoPSA was unaffected by the use of alpha 1-blocker (AUC[0.795)and 5-ARI (AUC[0.789)medications.Using IsoPSA, an estimated 47.1% of biopsies targeting high-grade disease could have been avoided in the validation cohort.CONCLUSIONS: IsoPSA displays superior diagnostic accuracy to total PSA and % free PSA in assessing the risk of high-grade PCa.Clinical use of IsoPSA would have resulted in a significant reduction in unneeded biopsies in low risk patients.IsoPSA also displays clinical utility in patients with symptomatic BPH on standard medication regimens.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3190210544