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Primary central nervous system lymphoma mimicking herpes encephalitis

Year: 2021

Type: article

Abstract: Primary central nervous system diffuse large B-cell lymphoma (PCNSL) is a rare B-cell non-Hodgkin lymphoma (NHL) of the CNS with highly variable clinical presentation.1,2 It can mimic other CNS conditions such as Herpes simplex virus (HSV) encephalitis which may delay the diagnoses and treatment leading to poorer outcomes. Therefore, a high index of suspicion for PCNSL must be kept in mind in patients with unusual CNS presentation or suboptimal response to therapy. We present a patient with MRI findings and HSV PCR consistent with HSV encephalitis who had no improvement on acyclovir and subsequently was diagnosed with biopsy-proven PCNSL. This study was conducted in accordance with ethical standards approved by the ethical research committee. Informed consent was deferred because of retrospective nature of study and non-identifiable patient data. A 74-year-old, previously healthy, immune-competent woman presented with new-onset confusion and progressive cognitive decline over 1 month. She had...

Source: Neuro-Oncology Practice

DOI: 10.1093/nop/npab036

Authors: Ifrah Zawar, Sung-Min Cho, Richard Prayson, Kerry Levin

Institutions: Cleveland Clinic, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: CNS Lymphoma Diagnosis and Treatment

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3190427942

FWCI:

Cites: 8

Cited by: 1

Related to: 10